People in two other cities are starting their weekend in relative freedom after the restrictions were eased overnight.
Health officials say 41, 177 vaccine doses were administered across the state within 24 hours to Friday night. Nearly 3.9 million jabs have been administered in total.
Victoria also conducted more than 73,000 virus tests on Friday.
Chief Health Officer Brett Sutton declared Friday night that residents of Mildura Rural City Council would be locked up from midnight.
There are now 12 active COVID-19 cases in the area, with health officials hoping the lockout will prevent the outbreak from escalating.
Mildura will be subject to the same rules of repatriation as Melbourne, excluding curfews, with a travel restriction of 15 kilometers and a ban on visitors to people’s homes.
Meanwhile, Greater Shepparton and Moorabool Shire left their lockdowns at 11:59 p.m. Friday, with rules now matching the rest of regional Victoria, including masks indoors and outdoors, and a ban on home meetings.
Professor Sutton paid tribute to the locals for helping bring case numbers down.
“I really thank everyone in the community for staying safe, staying apart and doing the right thing,” he said.
A small fine-tuning of the mask rules also took effect at midnight Friday, when adults could now remove their face mask to consume alcohol while outdoors.
Professor Sutton believes that Victoria’s coronavirus outbreak is nearing its peak.
1,838 infections and five deaths were reported Friday.
The health chief said rising vaccination levels ensured that the number of people admitted to hospital or admitted to intensive care did not grow as fast as the daily number of cases.