SARS-CoV-2 3CLpro also susceptible to mutations
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had a profound impact on society and the economy worldwide. Since its emergence at the end of 2019, extensive research has…
Mapping the trajectory of SARS-CoV-2 evolution inside the host
In a recent study posted to the bioRxiv* pre-print server, researchers in the United States mapped the trajectory of within-host evolution of acute severe respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.…
Fragment crystallizable-altered COVID-19 antibodies efficacious across two animal models
A recent article posted to the bioRxiv* preprint server identified numerous efficacious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies from convalescent SARS-CoV-2 patients. Study: Fc-modified SARS-CoV-2 neutralizing antibodies with…
Researchers map cancer driver mutations across the human genome
In a recent study published in Nature Biotechnologyresearchers explored the causes of cancer by mapping somatic mutation rates across the human genome. Study: Genome-wide mapping of somatic mutation rates uncovers…
SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases
In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus…
The potential mechanisms of SARS-CoV-2 to induce DNA damage
In a recent review published in Mutation Research / Reviews in Mutation Researchresearchers described potential mechanisms of coronaviruses that could lead to deoxyribonucleic acid (DNA) damage and the potential link…
Study investigates SARS-CoV-2 escape from nirmatrelvir
In a recent study posted to the bioRxiv* preprint server, researchers assessed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Alpha, Delta, and Omicron variants’ resistance to nirmatrelvir (NIR), a protease…
Where did Omicron’s unique spike gene insertion originate?
In a recent study posted to the medRxiv* pre-print server, scientists at nference Labs investigated the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) new variant of concern (VOC)…
Gastrointestinal complications caused by SARS-CoV-2
The sudden and rapid outbreak of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) pandemic, which has claimed more than 6.3 million lives worldwide…
Exploring virological profiles of recently emerged SARS-CoV-2 Omicron variants
In a recent study posted to the bioRxiv* preprint server, researchers explored the virological profiles of novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants. Study: Virological characteristics of…